中文名稱  DENN域內含蛋白2D抗體
別    名  DEN2D_HUMAN; DENN domain-containing protein 2D; DENN/MADD domain containing 2D; DENND2D.       
濃    度  1mg/1ml
規 格  0.2ml/200μg          
抗體來源  Rabbit  
克隆類型  polyclonal
交叉反應  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep  
產品類型  一抗    
研究領域  
蛋白分子量  predicted molecular weight: 54 kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human DENND2D
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品應用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復）
 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

DENN域內含蛋白2D抗體產品介紹 DENND2D is a 471 amino acid protein that contains a dDENN domain, a DENN domain, and a uDENN domain and exists as two isoforms as a result of alternative splicing. The DENND2D protein is thought to target to actin filaments and control Rab9-dependent trafficking of mannose-6-phosphate receptor to lysosomes. The gene encoding DENND2D maps to human chromosome 1, the largest human chromosome which spans about 260 million base pairs and makes up 8% of the human genome. Other notable genes located on chromosome 1 include LMNA, which is associated with the rare aging disease Hutchinson-Gilford progeria, and the MUTYH gene, which is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome.

Function : Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Similarity : Contains 1 dDENN domain.
Contains 1 DENN domain.
Contains 1 uDENN domain.
Database links : UniProtKB/Swiss-Prot: Q9H6A0.2