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大鼠C端甲狀旁腺激素ELISA試劑盒說明書
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詳細介紹
Rat C-Terminal PTH ELISA Kit
Rat C-Terminal PTH ELISA Kit INTENDED USE
This kit intended for research use only in the determination of rat CTerminal PTH in serum, plasma or cell culture media.
Rat C-Terminal PTH ELISA Kit INTRODUCTION
Rat intact parathyroid hormone (PTH) is an 84 amino acid polypeptide produced by the parathyroid gland with its biological activity residing in the N-Terminal region of the peptide. PTH plays an important role in maintaining the concentration of ionized calcium within the limits
needed to achieve normal metabolic functions. When serum calcium levels are decreased the parathyroid gland increases secretion from skeletal reserves into the circulation. When levels of serum calcium are increased the secretion of PTH is reduced. PTH undergoes extensive in-vivo catabolism producing numerous midregion and C-terminal fragments. These fragments have a much longer half-life in circulation than intact PTH and accumulate to high levels.Since PTH fragments are cleared from circulation by the kidney highly elevated levels can be seen with renal insufficiency.
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